Abstract

SYNTHESIS, CHARACTERISATION, ANTIMICROBIAL EVALUATION OF AZETIDINONE DERIVATIVE

S.Ramachandran*, S.Nandini, M.Noorul Hudha, Omer Abdul Gader, Otieno Winston Churchill, M.Rajasheik Nasrudeen Shah, Dr.R.Sundhararajan

ABSTRACT

A new series of N-(3-chloro-2-phenyl)-4-oxoazetidin-1-yl) isonicotinamide derivative were synthesized by the reaction of schiff base (isonicotinohydrazide and 4-hydroxybenzaldehyde) with chloroacetyl chloride respectively. The chemical structures of the synthesized compounds were confirmed by means of IR, 1H-NMR. . The synthesized compounds did not show antibacterial activity against Staphylococcus aureus and Escherichia coli.

Keywords: Antibacterial, Aromatic aldehyde, Isonicotinohydrazide, Chloroacetyl chloride, Schiff Base, Azetidinone