Abstract

REVIEW ON FORMULATION APPROCH OF SUSTAINED RELEASE TABLET DOSAGE FORM

Darkunde Jyoti Bahiru*, Patil Basavankita Suryakant and Dr. Amit Kasabe

ABSTRACT

The oral route is the most used route for the administration of drugs. Tablets are the most popular oral formulations available on the market and are preferred by patients and physicians. Sustained release dosage forms have been shown to improve therapeutic efficacy by maintaining a constant 2-3 fold plasma concentration of the drug. The use of polymers to support drug delivery has become an important tool in the formulation of dosage forms. Sustainable release can be achieved using HPMC together with crosslinking agents and other excipients used were PVP as binding agent, MCC as direct compressible agent and magnesium stearate as slip and lubricant respectively. The drug and excipients were subjected to a compatibility study using FT-IR, which suggested that there was no interaction between the drug and the excipients.

Keywords: Sustained release, compatibility, FT-IR, plasma concentration and therapeutic efficacy.