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Abstract

EFFICACY OF PERI-OPERATIVE ADMINISTRATION OF PRUCALOPRIDE IN ASSESSING POST-OPERATIVE BOWEL MOVEMENTS: A PROSPECTIVE COMPARATIVE STUDY

Shaik Bobby Parveen*, Madamanchi Manjusha, P. Seetharamaiah, Dr. S. Uma Shanker, Athina Jahnavi and Reddy Sucharitha

ABSTRACT

Aim: There is an extensive literature on the post operative bowel movements after abdominal surgeries. There are, however, few studies investigating the effect of prucalopride to treat post-operative constipation. The aim of the study is to identify the effectiveness of Peri-operative administration of prucalopride in assessing post-operative bowel movements after hernia repair surgery. Materials and Methods: The surgeon-blinded prospective randomized controlled study included 50 hernia repair surgery patients between the ages of 18 and 80. The patients were randomized into two groups: those who had prucalopride peri-operatively (n=25) and those who did not take prucalopride peri-operatively (n=25). The outcome measures were post operative first bowel movement, length of hospital stay, additional laxative need, adverse effects of the drug. Results: Among 50 patients, 28 patients were males (56%), 22 patients were females (44%). 2mg and 1 mg dose of prucalopride were given to 25 patients and the remaining half are taken without prucalopride. Out of 25 patients who Peri-operatively took prucalopride, 1 patient passed bowel on surgery day, 6 patients on day one after surgery and 18 patients on the second day after surgery without any complications and got discharged early. Whereas the 25 patients without prucalopride 2 patients passed bowel on day two after surgery, 5 patients on day three and 14 patients on day four, 4 patients on day five after surgery passed the bowel experiencing the complications of constipation and had delayed discharge from the hospital. Conclusions: The study suggests that peri-operative administration of prucalopride in hernia repair surgeries or any other abdominal surgeries effectively reduces postoperative gastrointestinal complications and shortens the recovery of bowel movements and length of hospital stay.

Keywords: Prucalopride, Bowel movements, Hernia repair surgery, Post –Operative constipation , Abdominal surgery.


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