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Abstract

FORMULATION AND EVALUATION OF TRANSDERMALPATCHES OF ANTIFUNGAL AGENT VORICONAZOLE

Chetankumar M.*, Prakash S. Jakkondi and Sandeep Chandakavate

ABSTRACT

Transdermal medication conveyance framework (TDDS) has been an expanded interest in the medication organization through the skin for both nearby restorative consequences for infected (skin conveyance) just as for fundamental conveyance of medications. Voriconazole is gotten from the construction of fluconazole by the substitution of one triazole moiety by a fluoropyrimidine gathering and alpha methylation. It is one of the generally utilized antifungal specialists for most sorts of parasitic contaminations including shallow and obtrusive contagious diseases. Transdermal remedial framework for Voriconazole were set up by dissolvable projecting technique utilizing different polymers like HPMC, EC and ERS100 in various suggestions. The patches were assessed utilizing different boundaries as weight variety, elasticity, dampness take-up, dampness misfortune, drug content and other huge boundaries. Chosen details were oppressed for solidness examines. The formulations T8-T14 showed a better in vitro drug release profile across the cellulose membrane, when compared to the other formulations. As far the above results were concerned formulations T1, T8, and T15 were selected and subjected for stability studies at room temperature and at 40ÂșC for a period of 45 days. The stability studies results signified that the formulated patches possess adequate shelf life till 45 days.

Keywords: Voriconazole, Transdermal drug delivery system, Patches.


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