Abstract

EVALUTATION OF ANTIOXIDANT POTENTIAL OF HEPATPPROTECTIVE HERBAL DRUG

Pravin M. Shahare, Payal N. Khandait and Tikesh R. Agrawal*

ABSTRACT

Liver is a vital organ play a major role in metabolism and excretion of xenobiotics from the body. Liver injury or liver dysfunction is a major health problem that challenges not only health care professionals but also the phar-maceutical industry and drug regulatory agencies. Liver cell injury caused by various toxic chemicals (certain anti-biotic, chemotherapeutic agents, carbon tetrachloride (CCL4), thioacetamide (TAA) etc.), excessive alcohol con-sumption and microbes is well-studied. The available synthetic drugs to treat liver disorders in this condition also cause further damage to the liver. Hence, Herbal drugs have become increasingly popular and their use is wide-spread. Herbal medicines have been used in the treatment of liver diseases for a long time. A number of herbal preparations are available in the market. The present review is aimed at compiling data on promising phytochemi-cals from medicinal plants that have been tested in hepatotoxicity models using modern scientific system.

Keywords: Herbal drugs, Liver Injury, Carbon tetrachloride (CCL4), Hepatotoxicity, Serum transaminases.