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Abstract

DESIGN AND CHARACTERIZATION OF PHYTOSOMES CONTAINING GREEN APPLE EXTRACT FOR ITS VARIOUS THERAPEUTIC APPLICATIONS

Viresh K. Chandur* and Ramakrishna Shabaraya A.

ABSTRACT

Phytopharmaceuticals stand out as recent promising candidates for the treatment of chronic diseases. Most of the bioactive constituents of phytomedicines are secondary metabolites like flavonoids. Flavonoids are phenolic compounds possess strong antioxidant activity. Poor drug dissolution is responsible for scarce absorption, poor bioavailability and high inter-subject variation following oral administration, The phytosome technology meets this challenge by markedly enhancing the bioavailability of phytomedicines. Apples represent potential sources of extractable flavanols for inclusion in functional foods. Quercetin conjugates are found exclusively in the peel of the apples. The optimum ratio of phospholipid to phytoconstituent 1:1, 3:1 and 1:3 ratio complex thus formed was isolated by lyophilization and subjected to phytochemical analysis (carbohydrates, flavonoids, saponins and tannins), FTIR, % yield (15.66%), drug content, entrapment efficiency(81.57, 82.34 and 83.22 % respectively), Partition coefficient (0.761, 0.782 & 0.821 respectively) and in vitro release studies was found to be (82.39%, 91.37% & 91.87% respectively).

Keywords: Phytosomes, Green apple, Flavonoids, Phospholipids.


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