Abstract

FORMULATION AND EVALUATION OF MEDICATED LIP BALM CONTAINING KETOCONAZOLE FOR TREATMENT OF EXFOLIATIVE CHEILITIS

Sneha Angel Joy*, Tina Raju, Lal Prasanth ML, Shibu Prasanth CR

ABSTRACT

Lip balms are formulations applied onto the lips to prevent drying and protect against adverse environmental factors. Organic lip balms nourish the lips and help to get hydrated and protect lips affected by chapping and dryness. They help to protect the natural health and beauty of the lips. Lip balms are not gender specific products and both men and women can use them. This research work focuses on the incorporation of natural waxes, sweetener, olive oil and colourant along with Ketoconazole for the treatment of a lip condition called Exfoliative cheilitis. The causative agent of this disease can be bacteria or fungus and other underlying causes also give rise to this condition. This formulation can help to keep lips hydrated and also nourished. Prepared lip balm was evaluated for organoleptic characteristics, melting point, spreadability, pH measurement, antimicrobial study, in- vitro diffusion and stability studies. After performing stability studies at room temperature (25.0 ± 3.0 ºC), refrigeration (4± 2.0 ºC) and oven temperature (40.0 ± 2.0 ºC) for 90 days. It was concluded that prepared lip balm shows uniform nature, perfect application, without any deformation at room temperature (25.0 ± 3.0 ºC) and at refrigeration (4± 2.0 ºC). Organic lip balm can be a better option for treatment of various lip problems.

Keywords: Ketoconazole, Exfoliative cheilitis, organic, lip balm, natural.