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Sheethal Lakum*, Shaik Muhammad Fazal Ul Haq and Sunitha Reddy M.


The objective of the present work was to formulate the proniosomal gel based suppositories of an antiretroviral drug, Atazanavir sulfate to improve its therapeutic efficacy for the treatment of HIV prevention. Proniosomal gel was prepared by co-acervation phase separation technique using cholesterol, soyalecithin and different types of surfactants such as spans(20, 40, 60, 80) and tweens(40, 80). And then formulated into suppositories using glycerinated gelatin as suppository base. Proniosomal gel were initially evaluated for optical microscopy, pH, entrapment efficiency and in-vitro diffusion studies and Proniosomal gel with greater drug entrapment efficiency was known to be optimized formulation. Optimized formulation was loaded into suppositories and evaluated for melting point, weight variation, pH, invitro-dissolution studies. Theaverage weight was in limits 0.8205, average M.P. for suppositories is found to be 37.03°C and the pH of suppositories was found to be in range 4.4-4.6. Proniosomal suppositories in-vitro dissolution studies showed sustained drug release when compared to proniosomal formulation. To overcome the drug leakage and stability of Proniosomal gel of Atazanavir sulfate, Proniosomal suppositories were formulated.

Keywords: Atazanavir, Proniosomal gel, Proniosomal suppositories, Non-ionic surfactant, Co-acervation phase separation, Cholesterol.

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