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Abstract

DEVELOPMENT AND VALIDATION OF UV-SPECTROSCOPIC METHOD FOR THE SIMULTANEOUS ESTIMATION OF CETRIZINE AND CHLORPHENIRAMINE IN TABLET DOSAGE FORM

Hafsa Siddiqua*, D. Sowmya, D. Keerthi, Atif Zama, Yousuf Bin Ahmed and Mustafa Ayad Mohammed

ABSTRACT

The present research work is focused towards development and validation of a simple, sensitive, rapid, accurate, precise and economical UV electro photometric method for the estimation of cetirizine and chlorpheniramine in tablet dosage form. This experiment is done based on the measurement of absorption maxima of cetirizine and chlorpheniramine at 230 nm and 262 nm respectively in 0.1N NaOH. The linearity range of cetirizine and chlorpheniramine was found to be 5-30microgm/ml and 10-60micro gm/ml respectively. The proposed method was statistically validated for its accuracy, precision and specificity.

Keywords: Cetirizine, Chlorpheniramine, 0.1N NaOH, UV spectroscopy.


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