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Abstract

FORMULATION AND EVALUATION OF SUBLINGUAL TABLET OF PAROXETINE HYDROCHLORIDE

Disha Shah*, Bhoomi Parmar, Drashti Nayak, Madhavi Chudasma, Manan Patel, Riddhi Trivedi

ABSTRACT

The sublingual tablet of Paroxetine hydrochloride was prepared by the direct compression method. The 50 mg tablets were devised using several concentrations of excipients like Pregelatinized starch as a binder, F-Melt M as a diluent, Sodium saccharine as a sweetening agent, Talc and Aerosil as a lubricant and a glidant respectively. Various pre and post evaluation parameters like hardness (kg), thickness (mm), diameter (mm), disintegration time (sec), %drug release at 9 mins, weight variation, friability, etc. were tested. Batch F6 was found to be the best batch with 2mg of Kyron T-314 and 1.25mg of Pregelatinized starch. The optimized batch was selected depending upon the minimum disintegration time and % cumulative release resulting into improvement in the bioavailability, drug efficiency and faster onset of action.

Keywords: Paroxetine hydrochloride, sublingual dosage form, bioavailability, first pass metabolism, disintegration time, Post-menopausal syndrome


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