Abstract

MONITORING OF AMINOGLYCOSIDES IN RENAL IMPAIRED PATIENTS

Umaima Farheen Khaiser*, Shobha R. Hiremanth, Jayantilal and Mohammed Kazim Sheriff

ABSTRACT

Renal failure is a medical condition in which kidneys fail to adequately filter waste products from blood. As a result, it causes alteration of the effect of many drugs, sometimes decreasing the effect or by increasing the effect leading to toxicity. The dose of the drug should be adjusted proportionally depending upon the drug clearance, lower the drug clearance higher the drug concentration. The study attempts to monitor the dosing of aminoglycosides in patients with renal impairment. A prospective observational study was carried out for 9 months in the year 2014-2015 at St Martha’s Hospital Bangalore India. The study was conducted in two phases; development and validation of aminoglycosides dosage adjustment protocol followed by monitoring the patients with renal impairment administered with aminoglycosides. The study included 17 patients undergoing haemodialysis in which 31 observations were on dosing of aminoglycosides. Weight of the patient was considered post haemodialysis amikacin of dose 500mg was the aminoglycoside majorly prescribed to the study patient. Upon monitoring, it was found that 27 observations required the dose of amikacin to be adjusted. Thus, the study stated most of the patients who were undergoing haemodialysis and are prescribed with aminoglycoside required dosage adjustment. Thereby improving the quality of drug prescription in patients with renal impairment could be of importance for improving quality of care.

Keywords: Renal failure, aminoglycosides, drug clearance, haemodialysis, dosage adjustments.