WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

SYNTHESIS, FORMULATION AND EVALUATION OF ANTIMICROBIAL GEL OF ISATIN DERIVATIVES

Soma Pramanik*, Vibha Patil and Kinjal Patel

ABSTRACT

A new series of 8-Amino-11H-5,7,9,10,11-pentaazabenzo[b]-fluoren- 6-ol derivatives were synthesized by condensing Isatin and its derivatives with 2,4,5-triamino-6-hydroxypyrimidinesulphate in aqueous medium. Later these compounds were converted into their corresponding Schiff’s bases by reacting with various aromatic aldehydes. The chemical structures of the synthesized compounds were confirmed by means of IR, 1H-NMR and Mass. Based on the microbiological screening of the synthesized compounds, 4L was selected for formulation of antimicrobial gel. The gel was formulated by changing the polymer ratio. Gel formulations were characterized for appearance, odor, pH, viscosity measurement, extrudability, spreadability, stability studies and antimicrobial study. Among the prepared formulations, gel prepared with 0.75% and 1% Carbopol were selected as the good carrier for synthesized compounds.

Keywords: Isatin, 2,4,5-triamino-6-hydroxypyrimidinesulphate, Schiff’s bases, Microbiological screening, antimicrobial gel.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More