Abstract

SYNTHESIS, FORMULATION AND EVALUATION OF ANTIMICROBIAL GEL OF ISATIN DERIVATIVES

Soma Pramanik*, Vibha Patil and Kinjal Patel

ABSTRACT

A new series of 8-Amino-11H-5,7,9,10,11-pentaazabenzo[b]-fluoren- 6-ol derivatives were synthesized by condensing Isatin and its derivatives with 2,4,5-triamino-6-hydroxypyrimidinesulphate in aqueous medium. Later these compounds were converted into their corresponding Schiff’s bases by reacting with various aromatic aldehydes. The chemical structures of the synthesized compounds were confirmed by means of IR, 1H-NMR and Mass. Based on the microbiological screening of the synthesized compounds, 4L was selected for formulation of antimicrobial gel. The gel was formulated by changing the polymer ratio. Gel formulations were characterized for appearance, odor, pH, viscosity measurement, extrudability, spreadability, stability studies and antimicrobial study. Among the prepared formulations, gel prepared with 0.75% and 1% Carbopol were selected as the good carrier for synthesized compounds.

Keywords: Isatin, 2,4,5-triamino-6-hydroxypyrimidinesulphate, Schiff’s bases, Microbiological screening, antimicrobial gel.