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Abstract

REVIEW ON SYNTHETIC SIGNIFICANCE OF RHODANINE NUCLEUS IN VARIOUS AILMENTS

Srinivasula Bhargavi Lakshmi Prasanna*, S. Udhaya vani and R. Govinda Rajan

ABSTRACT

An overview article described the study of 4-thiazolidinones particularly rhodanine ring and different systems for its reactions which fused the change of the ring and activities. Rhodanine is a 5-membered heterocyclic natural compound having a thiazolidine center. Furthermore, the reactivity of rhodanine ring which helped in the mix of different arylidenes at position 5 and carboxylic acids at position 3. The most responsive situations in 4-thiazolidinone are 3 and 5, which choose the significant headings of heterocycle change. Approaches to manage the association of 3,5-disubstituted 4-thiazolidinones in general join two pathways. Initially all the synthesis of 3,5-disubstituted 4-thiazolidinones by different reactions in position 3 of the thiazolidinone cycle. The second was the mix of 3,5-di subbed 4-thiazolidinones by various reactions in position 5 of the thiazolidinone cycle modification of 4-thiazolidinone cycle on positions 2, 3, 4 or 5 was productive to achieve made things with a wide scope of pharmacological development. Currently 4-thiazolidinones were considered as another class of antidiabetic (insulin sharpening) drugs and extreme aldose reductase inhibitors, which have the potential for the treatment of diabetes challenges (cataract, nephropathy, neuropathy).

Keywords: Rhodanine, 4-thiazolidine, Arylidenes.


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