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  • NOVEMBER 2020 Issue has been successfully launched on 1 November 2020

Abstract

ANXIOLYTIC ACTIVITY OF METHANOLIC LEAVES EXTRACT OF OCIMUM SANCTUM IN ALBINO WISTAR RATS

M.Prasada Rao*, T.Susmitha, A.Aparna jyothi, P.Santhi swaroop ,B.Suvarna kumari, M.Srilatha, K.Anvesh, P.Jyothi

ABSTRACT

The anxiolytic activity of ocimum sanctum leaf (200.400mg/kg) extract was monitored using the Elevated plus maze method taking Diazepam(2mg/kg) as the standard.It was observed that the leaf extract decreased the elevated levels ,significantly when compared to the standard (p<0.001), The cxtract showed asignificant increase in the number of open arm entries and also decreased the time spent in the closed arm (p<0.001).Thus the result suggest that the methanolic leaf extract of ocimum sanctum is a reliable anxiolytic agent.

Keywords: Anxiolytic activity,ocimum sanctum leaf extract, Elevated plus maze, Diazepam.


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