Abstract

NANOTECHNOLOGY BASED NOSE TO BRAIN DRUG DELIVERY FOR THE TREATMENT OF ALZHEIMER’S DISEASE: AN OVERVIEW

Ashwin D. Digarse* and Milind J. Umekar

ABSTRACT

Alzheimer’s disease is a neurological disorder resulting in behavioral and cognitive impairment in human, particularly yelderly person. As conventional treatment strategies, such as acetylcholinesterase inhibitor drugs, usually fails because of their poor solubility, lower bioavailability, and ineffective in crossing blood-brain barrier. Nanotechnologically, advanced treatment methods, which involve the design, characterization, production, and application of nanoscale drug delivery systems, have been employed to optimize therapeutics. Various nanocarriers that can be used are polymeric nanoparticles, microsphere, liposomes. These nanocarriers are promising tools for delivery of therapeutics to the brain via nasal route. The objective behind current study is to provide a systematic review on Nanotechnology- based Nose to Brain drug delivery system for the treatment of Alzheimer’s.

Keywords: Alzheimer’s disease, polymeric nanoparticles, microemulsion, nanotechnology