Abstract

NANOSUSPENSION - A NOVEL DRUG DELIVERY SYSTEM VIA NOSE TO BRAIN DRUG DELIVERY

Swetha R.*, Viresh K. C. and Shabaraya A. R.

ABSTRACT

The delivery of nanosuspension drugs to the brain through the nose is thought to be a promising path. When a faster onset of action and better patient compliance are required, this route is preferable to the others. This path is more permeable than the others in terms of permeability. This route allows a portion of the drug to bypass the hepatic first-pass metabolic processes, resulting in suitable bioavailability. Nanosuspensions can be produced using a variety of techniques. Many pharmaceutical and medical needs are addressed by new nanosupension innovations, ranging from improved life-cycle management to easy dosing for paediatric, geriatric and psychiatric patients. The various types of nanosuspensions dosage formulations, nanosuspensions preparation methods, nanosuspension stabilizers and characterization techniques, and factors influencing absorption are discussed in this review.

Keywords: Nanosuspension, bioavailability, nasal delivery, permeability, stability, solubility, absorption, homogenization, zeta potential.