Abstract

THE WOUND HEALING ACTIVITY OF CALENDULA OFFICINALIS: A REVIEW

Jakirul Islam*, Tapash Chakraborty, Asha Das, Damanbhalang Rynjah, Saranga Shekhar Bordoloi and Bitopan Baishya

ABSTRACT

Calendula officinalis belonging to the family Asteraceae, a commonly available medicinal plant, that has been traditionally found to have activity against several diseases counting skin infection, wounds, burns, and ulcers. Since the Calendula officinalis contains secondary metabolites like terpenoids, flavonoids, and carotenoids, which may have the potential activity in wound healing. It also possesses anti-cancer, anti-inflammatory, hepatoprotective, spasmolytic, and spasmogenic properties. Wound healing involves a composite series of interactions amid diverse cell types, cytokine mediators, and the extracellular matrix. The cascade of wound-healing actions starts with homeostasis, inflammatory cell conscription cell proliferation, and restoration. To compile existing knowledge on Calendula officinalis and highlight its wound-healing function, we focused at its phytochemistry, wound healing activities, including burns and ulcers, and toxicological data in this study. Conclusively, further research is necessary to determine whether Calendula has a potential role in standard wound management.

Keywords: Calendula officinalis, Wound healing, Burns, Ulcers.