Abstract

A REVIEW ON MICROSPONGE DRUG DELIVERY SYSTEM

Sahithi Uppuluti*, Sri lahari Tanniru, Raghavi Teddu and Hyma Ponnaganti

ABSTRACT

Microsponge is a recent novel technique to facilitate the controlled release of active drug. Microsponges has been introduced in topical drug products to provide the controlled releaseof active ingredient into the skin in order to reduce the systemic exposure and minimize local cutaneous reactions to active drug. Microsponge means a collection of very small, sponge like particles, having a large porous surface, used for drug delivery. Microsponge particles are also called as microsphere beads or microspheres, which are typically 10-25 microns in diameters. Microsponges can entrap various types of drugs and incorporated in formulations like, cream, powder, gels, and lotions. When applied to the skin, the microsponges releases the active drug on a time mode and also in response to other stimuli like, rubbing, pH, temperature, etc. Microsponges can provide increased efficacy for topically active agents with enhanced formulation flexibility, reduced side effects and improved aesthetic properties in an efficient and novel manner. Microsponge systems are non-irritating, non-mutagenic, non-allergic, non-toxic. Microsponge technology is being used currently in cosmetics, over-the-counter(OTC) skin care, sunscreens, and prescription products. The present review introduces microsponge technology, and its methods of preparation, evaluation methods and applications.

Keywords: Microsponge, controlled release, topical drug delivery, microsponge technology, targeted release.