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Abstract

A REVIEW ON PHARMACOKINETIC SIMULATION MODELS USED IN THE DRUG DEVELOPMENT

Manan Patel*, Dhruvi Dave, Nirav Shah, Dr. Riddhi Trivedi, Priyal Shah and Keshava Jetha

ABSTRACT

Drug and drug products have been a part of human society for a very long period of time. Simulation modeling is used to identify the pharmacokinetic behavior of drug inside the human body using preclinical data. The amount of the drug reaching systemic circulation depends on the initial concentration of drug, but still there are many parameters affecting drug pattern such as age, disease status, ethnicity of human pharmacokinetics, as well as drug-drug interaction, dose regimen. These simulation models can minimize number of clinical experiments in the formulation development as well as they help to reduce the cost of experiment. Many simulation models have been developed in the last decade in both the fields of pharmaceutical industry and academia, and are becoming an important part in drug discovery and development. All the information of simulation models are incorporated in this article, such as name, type and feature of the models. In this review, the methodology and concepts modeling of PBPK are briefly explained.

Keywords: Pharmacokinetics, Simulation, PBPK modeling, IVIVC.


[Full Text Article]

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