Abstract

STIMULI-RESPONSIVE CONTROLLED RELEASE SYSTEMS

Rashmi Madhariya*, Alpana Ram and Shruti Rathore

ABSTRACT

Optimizing the drug release to provide a continuous and prolonged supply of the drug to the systemic circulation has always been demanding. Out of a plethora of formulations to control drug release, stimuli-responsive delivery has emerged as a good option. Upon applying different stimuli such as light, magnetic field, heat, pH response, electric response, acoustic responsiveness, enzymes, or redox, functional materials change their physicochemical properties through physical transformation or chemical reactions, agreeing to the release of payload agents on demand. Determined efforts are being made to change these polymers synthetically because they hold massive potential in many fields such as polymer pharmaceutics, chemistry, materials science, bioengineering medicine, and chemical engineering. In addition to novel drug delivery, these smart polymeric systems have exhibited incredible applications in tissue engineering, regenerative biomedicine, molecular imprinting, gene delivery, cancer therapy, theragnostic, and other applications. The current review mainly deals with importance on the fundamental ethics involved during in situ gelling, the use of many “smart” drug-delivery formulations systems through some routes for their administration, as well as their well-documented biomedical applications.

Keywords: Stimuli responsive, pH responsiveness, Thermo responsiveness, Enzyme responsiveness, Near infra-red response, Photo Responsiveness.