Abstract

COMPARATIVE STUDY OF ANALGESIC ACTIVITY OF TWO INDIAN MEDICINAL PLANTS: JASMINUM SAMBAC & FICUS RECEMOSA L

Dhananjay.B. Deshmukh*, Kuntal G. Padwal & Dushant D. Gaikwad

ABSTRACT

Jasminum sambac & Ficus resemosa linn is an annual plant belonging to the family Oleaceae & Moraceae respectively found widely distributed in the region of South & southeast Asia, Europe, Malaysia and Australia. In folk medicine, the plant is used as tonic, aphrodisiac, antipyretic, antiseptic, antidiabetic and urinary tract anti-infections. The present study was undertaken to examine analgesic properties in the flower & fruit by ethanolic extracts in mice. The analgesic effect of ethanolic extracts was evaluated by ‘Tail flick method’ and ‘acetic acid-induced writhing test’ in mice by using Ibuprofen (30 mg/kg) as reference drugs. Ficus resemosa linn fruit ehanolic extract possess analgesic activity, but here we also used Jasminum sambac flower extract to check the extent of difference in activity. In the tail flick method with ethanolic extracts of Ficus resemosa linn fruit (400 mg/kg), the basal reaction time was increased significantly (p<0.01) and the percentage increase in threshold to pain was also significant as compared to standard & Jasminum sambac flower extrac . The ethanolic extract of fruit (400 mg/kg) possessed significant analgesic activity, as in acetic acid-induced writhing test, the writhing count was reduced significantly (p<0.01) compared to standard and flower ethanolic extracts.

Keywords: Jasminum sambac, Ficus resemosa linn., analgesic activity, acetic acid-induced writhing test, Tail flick method.