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Abstract

A REVIEW ON METHOD DEVELOPMENT AND VALIDATION OF PALONOSETRON BY DIFFERENT ANALYTICAL TECHNIQUES

Santhosh Illendula*, Nabeeda Raheman, Kandhala Jhansi, Baseera Banu, Shagoofa Shireen and Dr. K. Rajeswar Dutt

ABSTRACT

Pharmaceutical analysis plays a very prominent role in quality assurance as well as quality control of bulk drugs and pharmaceutical formulations. Rapid increase in pharmaceutical industries and production of drug in various parts of the world has brought a rise in demand for new analytical techniques in the pharmaceutical industries. As a consequence, analytical method development has become the basic activity of analysis. Recent development in analytical methods has been resulted from the advancement of analytical instruments. The improvement of the analytical method development and analytical instruments like UV, UPLC, LC-MS are required for reduced the time of analysis, increased precision and accuracy and reduced costs of analysis. Since the advent of the 5-hydroxytryptamine 3 receptor antagonists (5-HT3RAs) in the 1990s, dramatic improvements have been achieved in the field of antiemetic therapy. The enhanced prevention of delayed and overall chemotherapy-induced nausea and vomiting (CINV) offered by Palonosetron, a second-generation 5-HT3RA and aprepitant, the first neurokinin-1 receptor antagonists (NK-1RA) represent the only significant treatment advances in the past decade. While initial trials of single-dose indicated a potential benefit over first-generation 5-HT3RAs, only recently have new data become available, increasing the weight of evidence distinguishing it as a new 5-HT3RA in the class.

Keywords: Analytical method development, validation, Palonosetron, UV, UPLC, LC-MS.


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