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Abstract

METHOD DEVELOPMENT AND VALIDATION OF ULTRAVIOLET-VISIBLE SPECTROSCOPIC METHOD FOR THE ESTIMATION OF DEFLAZACORT IN ACTIVE PHARMACEUTICAL INGREDIENT FORM

Shagun Gogna, *Damandeep Kaur and Ajay Chaudhary

ABSTRACT

Objective: The objective of this work is to create a straightforward, proficient, and reproducible spectrophotometric strategy for the quantitative estimation of deflazacort in its active pharmaceutical ingredient (API) form. Methods: Spiked Deflazacort arrangement was checked over UV-visible extend for its wavelength of greatest absorbance. Different calibration guidelines of Deflazacort were arranged, and absorbance was recorded at wavelength of greatest absorbance. Calibration bend of concentration vs. absorbance was plotted and linearity and extend was calculated. Different expository strategy approval parameters viz. exactness, accuracy, LOD, LOQ, vigor and toughness were calculated utilizing QC guidelines. Results: The wavelength of most extreme absorbance for Deflazacort was found to be 244 nm. The relationship coefficient over the concentration extend of 1-10 μg/mL was found to be 0.9983. Created UV strategy was found to be exact amid the intra-day and inter-day and appeared percent relative standard deviation within the run of 0.21 to 1.60 & 0.21 to 1.62 individually. The full percent recuperation of Deflazacort was found to be 99.49 to 100.39 %. Created strategy was found to be strong and tough for the aiming utilize. Conclusion: A basic, exact and cost-effective UV- obvious spectrometry strategy for the estimation of Deflazacort was created. The said strategy was created utilizing conservative rate of natural stage in fluid media as dissolvable. Said approved UV- unmistakable strategy can be effectively utilized for the estimation of Deflazacort in API frame as per the administrative prerequisites.

Keywords: Deflazacort, Dilutions, Steroids, Ultraviolet-visible spectrophotometry, Validation.


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