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Ahmed Mohamed El Mahdy*, Jihan Mostafa Badr and Mogda Kamel Mansour


The current research looked into the effects of consuming Bacillus Coagulans spores-based probiotic in the ration and/ or colistin sulphate supplementation in drinking water on Salmonella Enteritidis intestinal colonization, immunoglobulin's formation, weight gain, clinical signs, and mortality rate of broiler chicks. One hundred Salmonella-free, 1 day-old, cubb chicks were divided to 5 equal groups (20 hicks per group). Chicks in groups 2, 3, 4, and 5 were infected orally with 10×106 cfu/ml of Salmonella Enteritidis field strain given on the 3rd day of age. Chicks in group 1 were neither infected nor treated (negative control). Chicks in the 2nd group were infected with Salmonella Enteritidis (positive control), while chicks in the 3rd group were received Bacillus Coagulans spores-based probiotic. Chicks in group 4 were given colistin sulphate and chicks in group 5 were given both Bacillus Coagulans spores based probiotic and colistin sulphate. Using student T-test, statistical analysis for results of intestinal colony count of Salmonella Enteritidis revealed a highly significant decrease (P<0.001) in cecal Salmonella count compared to the positive control group at both day 28 and 35 of age between groups received Bacillus Coagulans spores based probiotic and/or colistin sulphate and the positive control group. Furthermore, the broiler chicks treated with the combination of probiotic supplements and colistin sulphate had a minimal viable intestinal colony count of Salmonella Enteritidis with mild clinical signs, The statistical analysis for results of body weight gain by using student The T-test revealed a substantial difference at p<0.01 between the groups using Bacillus Coagulans spores dependent probiotics and colistin sulphate in combination and negative control group Although all other groups and the negative control group had major differences at p<0.05. There was a rising in the mortality rate from (5%) for group that infected and treated with probiotic and colistin sulphate and (10%) for the two other infected and treated groups to reached (20%) for the positive infected non-treated group. The statistical analysis for results of immune globulins using ANOVA test revealed that co-administration of colistin sulphate and Bacillus Coagulans based probiotic led to improved immune response. From all aforementioned data, we concluded that the supplementation of Bacillus Coagulans spores based probiotic feeds formulation in combination with colistin sulphate was increased the resistance of broilers to Salmonella Enteritidis infection with improving immunity.

Keywords: Bacillus Coagulans spores based probiotic, colistin sulphate, Salmonella Enteritidis, immunity and broiler.

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