Abstract

PRELIMINARY PHYTOCHEMISTRY, IN VITRO AND ESTIMATION OF ENZYMES WITH ANTIDIABETIC STUDY OF CHICKEN WEED PLANT EXTRACT

Logeshwari B.*, Vani M., Kaviya Priya R. and Madhumitha G.

ABSTRACT

Diabetes mellitus (DM) is global health problem and the incidence of DM is increasing at alarming rate all over the world. The present study aimed to evaluate antidiabetic activity of ethanolic extract of Chicken weed which is also called as Portulaca quadrifida L. on Streptozotocin induced diabetic rats. Diabetes was induced in male Wistar rats by single intraperitoneal injection of streptozotocin (150mg/kg b.wt.). The diabetic rats were administered orally with Portulaca quadrifida L. plant extract at two different doses (200 and 400 mg/kg b. wt/day) for 21 days and compared with standard drug glibenclamide (5mg/kg b.wt./day) treated rats. The results of streptozotocin treated diabetic control rats showed a significant increase in blood glucose with concomitant decrease in body weight. Oral administration of Portulaca quadrifida L. extract (200 and 400 mg/kg) and glibenclamide (5mg/kg) for 21 days showed significant reduction in blood glucose levels, an elevation in the body weight, Lipid levels and histopathological studies as compared to diabetic control rats. The present study showed that Portulaca quadrifida L. extract possess potent antidiabetic activity.

Keywords: Diabetes mellitus, Chicken weed, Portulaca quadrifida, glibenclamide, Blood glucose, Streptozotocin.