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Abstract

A NOVEL RP-TLC DENSITOMETRY METHOD BASED ON GREEN SCIENCE FOR ESTIMATION OF APIXABAN IN TABLET DOSAGE FORM

M. P. Jyothi*, Amey Dumbre, Shreya Thakur, Purva Vaishampayan, Rutuja Gharat,
Sanjeev Singh

ABSTRACT

Present study describes a RP-TLC densitometry method based on green science. Reverse Phase TLC plates coated with C-18 silica gel along with a mobile phase comprising of two eco- friendly solvents, ethanol and water (7:3) were used to achieve the separation. The developed method was validated as per the ICH guidelines. Linearity was in the range of 30- 80 ng/band with an r2 value of 0.996. The % RSD for repeatability and inter-day precision studies were found to be well below 2 %. Limit of Detection and Limit of Quantification were 3.82 ng and 11.5 ng per band respectively. The technique was found to be suitable for quantification of apixaban in commercial tablet formulation. Features like usage of benign solvents, less solvent and energy consumption were designed in to improve the greenness profile. A widely used assessment tool ―Analytical Eco scale‖ was used to establish the finer green character when compared to published HPTLC methods.

Keywords: Apixaban, RP-HPTLC, Green, Eco-Friendly, NEMI, Eco-Scale.


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