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Abstract

SYNTHESIS OF NOVEL BENZAMIDE AND ARYLIDENE DERIVATIVES OF 1H-IMIDAZO[4, 5-B]PYRIDINES

A. Jeyanthi*, B. Kusuma and Dayakar Gade

ABSTRACT

The chemistry of benzamides has gained importance in recent times, as most of them showed pronounced bioactive property. Benzamides are identified as important structural unit present in many compounds having potential biological activities, which are extracted from natural sources. For example, molecules, like proteins which play a essential role in almost all biological processes such as enzymatic catalysis, transport/storage (haemoglobin), immune protection (antibodies) and mechanical support (collagen). In amide all the three atoms in the O–C–N chain are reactive which makes them a useful moiety in organic compounds and hence become a key part for medicinal chemists. Some of the naturally occurring amides are Capasaicin Piperine, and Penicillin. Therefore, keeping in view of the varied pharmacological properties of both Imidazo[4,5-b]pyridine and benzamide moiety, a novel series of N-(substituted phenyl)-4-(1H-imidazo[4,5-b]pyridin-2-yl)benzamide derivatives and N-(4-substituted arylidene)-4-(1H-imidazo[4,5-b]pyridin-2-yl)anilines were synthesised for the first time by appropriate synthetic routes and screened for antimicrobial activity.

Keywords: Pencillin, Piperine, Capasaicin, Collagen, Haemoglobin, Analgesic activity.


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