Abstract

INFLUENCE OF THE COMPONENT EXCIPIENT ON THE FUNCTIONALITY OF BIPHASIC DELIVERY SYSTEM OF LORNOXICAM CAPSULE IN CAPSULE

Viresh K. Chandur*, Bhavya Shree T., Narasimharaj A. and Shabaraya A.R.

ABSTRACT

The biphasic drug delivery system contains two different release phases- an immediate release phase and an extended-release phase. This type of system is primarily used when maximum relief needs to be achieved quickly and it is followed by sustained release phase to avoid repeated administration. Immediate release tablets containing loading dose (3.25 mg) of Lornoxicam were prepared by using PVP K-30 as carrier 1:1 and 1:2 ratio and Magnesium oxide as a buffering agent in order to create a favourable microenvironment for drug release. The sustained release beads of Lornoxicam were prepared by ionotropic gelation technique using sodium alginate alone and in combinations with HPMC, Pectin and Chitosan in different concentrations containing equivalent to 12.75mg of Lornoxicam as maintenance dose. The capsule in capsule system was developed by placing beads filled enteric coated capsule cross linked with formaldehyde vapours inside a normal hard gelatine capsule containing immediate release tablet (Disintegration time 3 min, Drug content 96.61% and 98% release at the end of 150 sec) and sustained release beads evaluated for drug content, entrapment efficiency and pre-formulation evaluations. The drug release from biphasic delivery system in simulation of GI transit condition was achieved by altering the pH of dissolution medium at different time intervals. The pH of the dissolution medium was kept 1.2 for 2 hours and pH 6.8 for next 9 hrs. Showed F1 (HPMC) 96.65%, F2 (PECTIN) 97.15%, F3 (CHITOSAN) 98.61% release. Based on the release kinetics, it was concluded that the biphasic delivery system of lornoxicam followed zero order release kinetics.

Keywords: Lornoxicam, Biphasic release, immediate release, inotropic gelation, enteric coated.