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Abstract

FORMULATION AND EVALUATION SUSTAINED RELEASE MATRIX TABLET OF DULOXETINE HYDROCHLORIDE

Deepak K. Singh*, Brajesh K. Arjariya and Praveen K. Jain

ABSTRACT

The overall objective of the present work was to develop an oral sustained-release (SR) Duloxetine HCL Tablet that is prepared by the direct compression method by using manila copal, pectin and Guar gum polymer alone as well as in combination at different concentrations. Duloxetine HCL is a biguanide that has a relatively short plasma half-life. It has low absolute bioavailability. All the properties were evaluated for thickness, weight variation, hardness and drug content uniformity and in vitro drug release. The mean dissolution time is used to characterize the drug release rate from a dosage form that indicates the drug release-retarding efficiency of the polymer. The hydrophilic matrix of HPMC alone could not control the Duloxetine HCL release effectively for 12 h but when combined with Guar gum, it could slow down the release of drug and, thus, can be successfully employed for formulating Sustain Release matrix tablets.

Keywords: Guar gum, manila copal, matrix tablets, release kinetics.


[Full Text Article]

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