Abstract

ADVANCEMENT IN THE SUSTAINED RELEASE MATRIX TABLET SYSTEM

Archna Gautam*, Dev Raj, Vinay Pandit and M. S. Ashawat

ABSTRACT

Tablet is one of the most common and popular oral pharmaceutical oral dosage forms. Oral ingestion is most convenient and commonly employed route of drug delivery due to its ease of administration, least aseptic and flexibility in the design of dosage form. It is well known that modified release dosage forms may offer one or more advantage over immediate release formulation. One of such modified release dosage form is matrix delivery system, in which drug is uniformly dissolved or dispersed throughout the polymer matrix. In matrix diffusion- controlled system, the drug reservoir is prepared by homogenously dispersing drug particles in a hydrophilic or lipophilic polymer matrix. The resultant polymer is then molded into a medicated disc. Matrix system is one of the most innumerable methods used in the development of SR formulation. In simplest word, matrix is defined as a well composite of one or more drug with a gelling agent. Studies demonstrate that drug delivery from this system may reduce the side effect associated with the NSAIDs and provide extended therapeutic effect. The goal of this review article is to discuss the release mechanism of the drug dosage form of various polymers and a matrix system used in preparation of matrix tablets.

Keywords: The resultant polymer is then molded into a medicated disc.