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  • WJPPS NOVEMBER ISSUE PUBLISHED
  • NOVEMBER 2020 Issue has been successfully launched on 1 November 2020

Abstract

HYPOLIPIDEMIC EFFECT OF CALOTROPIS GIGANTEA SEEDS EXTRACT ON HIGH FAT DIET INDUCED ATHEROGENIC RATS

Jatin Jaiswal *, Hemant Bhardwaj, Dr. Ch. V. Rao, Nisha Sharma

ABSTRACT

Objective: The present study was designed to evaluate the hypolipidemic activity of Calotropis gigantea seeds on high fat diet induced atherogenic rats. Methods: The acute toxicity studies were performed on mice while adopting the OECD-420 Guidelines (fixed dose procedure). The hypolipidemic effect of plant seed extracts was evaluated on the standard 28 days model. Results: Treatment with methanolic extract of Calotropis gigantea (MECG) seeds at the dose 200 mg/kg and 400 mg/kg body weight showed the significant decrease in the total cholesterol levels, triglycerides levels, VLDL-c and LDL-c levels, whereas there was slight increase in HDL-c levels.The activities were also compared with the effects produced by the standard anti-hyperlipidemic drug, atorvastatin 10 mg/kg. Conclusion: The present findings indicate that the seeds of Calotropis gigantea has a potent hypolipidemic effect on HFD induced atherogenic rats.

Keywords: Madar, Calotropis gigantea, OECD, MECG, streptozotocin and glimipride


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