Abstract

NANOSPONGES: AN OVERVIEW ABOUT THE NOVEL CLASS OF DRUG DELIVERY SYSTEM

Mamtha D. P.*, Viresh K. C. and Shabaraya A. R.

ABSTRACT

The latest development in nanotechnology shows the increased concentration that is at present existence turn out to be the supramolecular gathering of simple constituents for therapeutic and diagnostic implementation. This review provides the detail information about materials used in the manufacture of nanosponges, different methods of preparation, characterization, and applications. Targeted drug delivery to specific sites is important problem which is being faced by the medical researchers. The new developed colloidal system called nanosponge has ability to defeat these problems. They are new class of highly cross-linked polymer found colloidal structures containing of solid nanoparticles with nanosized cavities and colloidal sizes. They increase stability, decrease side effects, and improve drug release. The outermost surface is typically porous, permit sustain release of drug to sites, prohibit drug and protein degradation. Nanosponges are tiny sponges with a size of about a virus, which can be incorporated with a wide variety of drugs. These minute sponges can be distributed around the body until they come across the specific target site and stick on the surface and begin to release the drug in a controlled and predictable manner. By changing the number of cross-linkers and polymers, the nanosponge particles can be made huge or tiny size. These particles can transport both lipophilic and hydrophilic substances and enhance the solubility of poorly water-soluble molecules. It has various applications like improves bioavailability of drugs and delivery of drugs into oral, topical as well as parenteral routes.

Keywords: Nanosponges, Nanotechnology, Encapsulation, Cyclodextrin, Sustain drug delivery.