Abstract

REVIEW ON PATHOPHYSIOLOGY AND RECENT DEVELOPMENTS IN THE TREATMENT OF ATHEROSCLEROSIS

Theja N. J.*, Kusu Susan Cyriac, Sarita Sharma

ABSTRACT

Recent years have brought a great amount of new outcomes in the field of atherosclerosis. A superior comprehension of the role of various lipoprotein particles in the arrangement of atherosclerotic plaques is presently conceivable. Recent cardiovascular clinical preliminaries have additionally revealed more insight upon the adequacy and wellbeing of novel mixtures focusing on the principle pathways of atherosclerosis and its cardiovascular difficulties. Recently, statins have been found to deliver genuine poison levels, which are uncommon but can be possibly unsafe and are noise worry for the prompt need to build up some new synthetic substances in this class. This survey is fundamentally concerned with late improvements in atherosclerotic medication disclosure including novel inhibitors of cholesterol biosynthesis, cholesterol ingestion inhibitors and cell reinforcements. The review additionally centers around conceivable future targets including quality treatment.

Keywords: Atherosclerosis, Plaque Progression, HMG CoA synthase (HS) inhibitors, squalene epoxidase, squalene synthase.