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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2020
Citation	6651	4087
h-index	26	21
i10-index	174	83

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WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2025 Issue has been successfully launched on 1 NOVEMBER 2025.

Abstract

THERAPEUTIC EFFECTS OF ZANTHOXYLUM TETRASPERMUM W.A. STEM BARK ON CARBOHYDRATE METABOLIZING ENZYMES IN MAMMARY CARCINOMA MICE

Mr.Narayanasamy K.* and Dr.Ragavan B

ABSTRACT

Mammary carcinoma is a heterogeneous disease that appears to progress from an in situ tumor to invasive cancer. Little is known about the molecular events driving this progression. The genus Zanthoxylum is known as “Timoor” that is used as mouth fresh, tooth care and spice. Zanthoxylum tetraspermum (Wight & Arn.) belongs to the family“Rutaceae” possesses some biological activities. The present study evaluated the effect of Z.tetraspermum stem bark extract (300 and 600mg / kg body weight) in liver and kidney of N-methyl-Nnitrosourea (MNU) induced mammary carcinoma mice on carbohydrate metabolizing enzymes and pentose phosphate pathway enzyme. Mammary carcinoma-bearing mice showed a significant (P

Keywords: (5-FU) as positive drug control group showed no significant variations in enzyme activities. The results obtained in the present study indicate the therapeutic effect of the stem bark extract and validates the traditional use of this plant in mammary carc

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