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K. Ramya Krishna*, G. Madhavi and K. Padmalatha


The enhancement of oral bioavailability of poorly water soluble drugs remains one of the most challenging aspects of drug development. A more recent technique powdered solution technology, or liquid solid technology, has become more applied to prepare water-insoluble drugs into rapid release solid dosage forms. The poorly dissolution rate of water insoluble drugs is still a substantial problem confronting the pharmaceutical industry. At present 40% of the drugs in the development pipelines, and approximately 60% of the drugs coming directly from synthesis are poorly soluble. Liqui-solid technique is a new beneficial and promising approach to overcome this consequence and that can change the dissolution rate of water insoluble drugs. According to the novel formulation methods of liquid solid compacts, liquid medications such as solutions, suspensions, of water insoluble drugs in suitable non-volatile liquid vehicles can be converted into acceptably flowing and compressible powders by blending with selected powder excipients. Dissolution rate and bioavailability can be increased by liqui-solid technique.

Keywords: Liqui- solid technique, Non-volatile liquid vehicles, Bioavailability.

[Full Text Article]

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