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  • WJPPS NOVEMBER ISSUE PUBLISHED
  • NOVEMBER 2020 Issue has been successfully launched on 1 November 2020

Abstract

FORMULATION AND EVALUATION OF KETOROLA TROMETHAMINE AND RABEPRAZOLE SODIUM BILAYERE MATRIX TABLET-30mg&20mg

Kotta Kranthi Kumar*, Guru Prakash, Shaik Naseeb Basha

ABSTRACT

Bilayer tablets were prepared by using combination of immediate release rabeprazole sodium along with sustained release ketorolac tromethamine. The FTIR study conducted using a combination of drugs along with excipients and polymers revealed that combination can be safely prepared. Rabeprazole sodium was formulated as immediate release layer using sodium starch glycolate, croscarmellose sodium, crospovidone as super disintegrants. The optimized rabeprazole sodium immediate release (IR 9) with highest in-vitro release was selected. Ketorolac tromethamine was formulated as sustained release layer using different grades of HPMC polymers and evaluated for in-vitro release studies. Bilayer tablets were prepared by double compression of optimized batch (F5) ketorolac tromethamine sustained release layer and rabeprazole sodium immediate release layer. All the physical parameters were in acceptable limit of pharmacopoeial specifications. Hence bilayer tablets of ketorolac tromethamine and rabeprazole sodium could be used to improve patient compliance towards the effective management of post operative pain, osteoarthritis without side effect of gastric irritation.

Keywords: Ketorolac tromethamine, Rabeprazole sodium, bilayer tablets, immediate release layer, sustained release layer.


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