Abstract

INCIDENCE OF MUPIROCIN RESISTANT MRSA IN CLINICAL SAMPLES FROM A TERTIARY CARE HOSPITAL IN NAVI MUMBAIA NEWER THREAT IN MANAGEMENT

Anahita Hodiwala*, Harapriya Kar, Vivek Shrivastav

ABSTRACT

Background: Detection of methicillin resistant Staphylococcus aureus in clinical samples continues to be important, since infections due to MRSA (Methicillin Resistant Staphylococcus aureus) have a high morbidity and mortality. Mupirocin is a topical antibiotic used to treat and control spread of MRSA. The existence of mupirocin resistance among MRSA is a cause of concern. Methods: All MRSA strains were identified using standard microbiological techniques and their susceptibility was tested using 5μg and 200 μg disc using disc diffusion method. Results: Out of 240 S. aureus isolates, 172 were found to be hospital acquired and 68 were community acquired strains. It was seen that MRSA amongst hospital acquired isolates was 7% and amongst community acquired was 6 %. Maximum number of S. aureus was isolated from pus samples i.e. 122/240 (50.8%) followed by urine i.e. 20/240 (8.3%). Community acquired S. aureus isolates showed maximum sensitivity to Ampicillin, Amoxycillin, Linezolid, Vancomycin and Netillin, on the other hand hospital acquired S. aureus isolates exhibited high degree of resistance to Ampicillin and Amoxycillin. Out of 240 S. aureus strains, 16 were MRSA (6.66 %). Out of 16 MRSA, highest number of isolates i.e. 12 (75%) were from blood. 04 MRSA were isolated from community and 12 were from hospital setting. Conclusion: The rising incidence of Mupirocin resistance can be a matter of concern because there are not many effective alternatives for mupirocin resistant strains. Indiscriminate uses of antibiotics have lead to emergence of many resistant clones of bacteria making treatment more and more difficult with each passing day. Hence a detail study is required with regard to proper antibiotic usage to find out the different resistance patterns amongst isolates.

Keywords: Staphylococcus aureus, Methicillin Resistant Staphylococcus aureus, mupirocin and antibiotic resistance.