Abstract

SERUM ANTIMULLIRIAN HORMON AND ANTRAL FOLLICLE COUNT PREDICT OVERIAN RESPONSE IN IVF CYCLE

*Dr. Batool Jumaa Al-Maliky, Dr. Kawther Abdalabbas AL-Fatlawy and Dr. Nada Al-Ibrahimi

ABSTRACT

Invitro fertilization is one method of treatment of infertility. There are many hormonal markers used for follow up and prediction of IVF cycle outcome. AMH is a new marker for ovarian reserve during their reproductive life. Aim of study: To investigate whether AMH level and antral follicle count are associated with ovarian response and pregnancy outcome in IVF cycle. Design: This was prospective, comparative, and analytic study. Material and methods: It was carried out in Fertility center of Al-Sadar Teaching Hospital in Al-Najaf city between April 2012 to July 2012. Total of 81 infertile women were enrolled in our IVF program were recruited for the prospective study, subdivided our patient to 3 groups cancel group and good responder and poor responder according to their oocyte numbers. Result: When we compared AMH between cancelled group and completed group, the cancelled group had a highly significant lower level of AMH (0.73) The completed cycle AMH (2.02) p < 0.001. There are no significant differences in cycle day2 follicular stimulating hormone, luteinizing hormone, estrogen Levels between two groups. The pregnancy rate was higher significantly in good responder 32-60% compared with poor responders which was 0.0%. A cut off AMH level in the prediction of cycle cancellation a cut off >= 0.8ng/ml had the best sensitivity (90%) and specificity (65%) for prediction of cycle cancellation. Conclusion: In this preliminary study, we found that AMH serum level and AFC are associated with ovarian response in ART cycle better than the usual hormone markers and can be used to serve as a novel marker for ovarian reserve. Aim of the study: To investigate whether anti-mullerian hormone levels and antral follicle count are associated with ovarian response and pregnancy outcome for in vitro fertilization (IVF).

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