Abstract

VARIATION OF BIOCHEMICAL MARKERS IN PATIENTS WITH COVID -19 IN ETHNIC KASHMIRI POPULATION - AN OBSERVATIONAL STUDY

Rafia Rasool, Gowhar Rashid, Syed Douhath Yousuf, Shafat Ahmad Mir and Syed Mudassar*

ABSTRACT

Background: The outbreak of the COVID-19 pandemic emerged in China; its effects permeated through all the nations and brought worldwide mortality. This study was conducted on an indigenous community of Kashmir valley. We aimed to observe the impacts of the novel coronavirus infection on the biochemical parameters of affected patients. Method: A total of 288 COVID-19 positive patients both male and female were recruited. The confirmation of being positive was done by Real-time PCR and same day their biochemical investigations like of liver function test, kidney function test, LDH and CPK levels were recorded. Results: Among different biochemical parameters, Urea was found to be elevated in COVID -19 patients The average Urea concentration was 73.90 mg/dl. ALT levels were found to be elevated among liver enzymes. ALT had an average value of 53.94 U/l. LDH levels were also elevated significantly. The average LDH level in COVID -19 patients was 337.25 U/l. The differences in Urea, Creatinine, ALT, and CPK levels between males and females were statistically significant (P value <0.05). Albumin levels have decreased in 71.96 % of males and 68 % of females. Furthermore, it was found that COVID-19 affected people of all ages, with children being least affected. Conclusion: In patients with COVID-19, we found elevated levels of LDH, liver enzymes (ALT), and Kidney function parameters, indicating that the disease has a multi-organ effect.

Keywords: Biochemical markers, COVID -19, CPK, LDH.