Abstract

SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF NEW SERIES OF CARBAZOLE BASED DERIVATIVES

Amit Kumar Dwivedi*, Sujeet Kumar Gupta and Shobhit Srivastava

ABSTRACT

To synthesized a novel series of substituted carbazole derivatives and their anti-inflammatory activity evaluated by using a carrageenon induced inflammation in rat paw edema model. In first step employing Vilsmeier Haack Reaction, the phosphorous oxychloride (POCl3) was added dropwise in N, N-Dimethylformamide (DMF) at 0-5C with stirring for 30 minute (0-5C). Then the POCl3 and DMF solution was added to carbazole and refluxed for 2 hrs. at 75-80C to form 2-chloro-9H-carbazole-3-carbaldehyde as intermediate compound (2). Ahead employing claisen-schmidt condensation reaction compound (2) was treated with various acetophenone derivatives in the presence of ethanol and sodium hydroxide solution afforded 3-(2-chloro-9H-carbazol-3-yl)-1-(substituted)prop-2-en-1-one (4a-e) derivatives as a final compound. Thin layer Chromatography was used to check the completion of reaction. All the synthesized compounds structures confirmed by 1H NMR, MS and FT-IR. Carrageenan Induced Inflammation in rat paw edema model used for anti-inflammatory activity in pharmacological screening. The compound (4d) & (4e) shows moderate activity compared with the standard drug Diclofenac sodim.

Keywords: Carbazole, Anti-inflammatory activity, Carrageenan Induced Inflammation in rat paw edema model.