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Dr. Jigar Vyas, Patel Nidhi*, Mehvish Nagamia, Parikh Jahanvi and Patel Ayushi


This study was performed to develop a topical cream of Diclofenac-Na which has potent anti-inflammatory activity by oral administration. At first, research was carried out on the cream base which influences the external anti-inflammatory effect of the drug. Cream of Diclofenec-Na were prepared with base of Bee-wax and Coconut butter. The cream was found to have potent effect. Therefore, in next, an optimum concentration of diclofenac –Na in cream was determined comparing the anti-inflammatory effect among the Gel preparations containing 1% of the drug. Result: Obvious effect were observed with the cream and a Gel containing 1.0% diclofenac Na and was adopted as the external topical formulation of the drug for anti-inflammatory effect.

Keywords: Diclofenac-Na, Olive oil, Coconut butter, Borax, Extract of Tulsi and Neem, Beewax.

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