Abstract

A COMPARATIVE STUDY OF METFORMIN ADMINISTRATION AFTER FOOD AND BEFORE FOOD IN THE TREATMENT OF TYPE 2 DM.

Geetha R.*, Mahadevamma L., Ranjitha V., Manoj D.H. and M. Mohitha

ABSTRACT

Objectives: The objective of this research was a comparative study of metformin administration after food and before food in the treatment of type 2 DM. Methods: This was a prospective and observational study carried out for a period of 06 months at Uttarahalli, Public health center, Bengaluru rural, by enrolling the subjects based on criteria. Data were analyzed using the suitable statistical tool. Results: A total of 92 patients were enrolled in the study, the majorities 52 were female and 40 were male respectively. Most of the patients (8.7%) were in the age group of >65yrs. The given population showed that 50 patients were advised to administer metformin before food and 42 patients were advised to administer metformin after food. Patients have undergone six follow-ups according to FBS, PPBS, and RBS levels. In which based on FBS levels the 5th and 6th follow-up have significant differences concerning before food administration of metformin. Based on PPBS levels the 6th follow-up has a significant difference concerning before food administration of metformin. Conclusion: Metformin was the most commonly used anti-diabetic agent in combination with glimepiride. As the benefits of metformin use clearly outbalance the risk of side effects which shows before food administration of metformin is better than after food in the patients who are having FBS level higher than the normal level. Most of the patients had well-controlled blood glucose levels in the fasting stage hence the therapy was found to be effective before food.

Keywords: Diabetes, Metformin, Patient-specific management, Combination therapy.