Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS APRIL ISSUE PUBLISHED
  • APRIL 2021 Issue has been successfully launched on 1 April 2021.

Abstract

SYNTHESIS, CHARACTERIZATION & PHARMACOLOGICAL EVALUATION OF SOME NOVEL QUINOLINE DERIVATIVES

Rudra Pratap Singh*, Shivam Jaiswal, Shobhit Srivastava, Bhumika Yogi and Sujeet Kumar Gupta

ABSTRACT

A series of newer 2-((Z)-2-((5-chloro-3-methyl-1-(substituted)-1H-pyrazol-4-yl)methylene) hydrazinyl)quinoline-3-carbaldehyde (7a-e) derivatives was synthesized through acetanilide (1). In the first scheme, 2-chloro-3-formylquinoline (2) was prepared using acetanilide (1) by Vilsmeier-Haack reagent (DMF+POCl3).The 2-chloro-3-formylquinoline was further treated with hydrazine hydrate and ethanol which yield2-hydrazinylquinoline-3-carbaldehyde (3). In the second scheme,5-chloro-1-(substituted)-3-methyl-1H-pyrazole-4-carbaldehyde (6a-e) was synthesized through the reaction of substituted phenylhydrazine with ethylacetoacetate in the presence of diluted ethanol. In the third scheme, above synthesized compound 2-hydrazinylquinoline-3-carbaldehyde (3) and 5-chloro-1-(substituted)- 3-methyl-1H-pyrazole-4-carbaldehyde (6a-e) was again treated with Vilsmeier-Haack reagent (DMF + POCl3) to yield 2-((Z)-2-((5-chloro-3-methyl-1-(substituted)-1H-pyrazol-4-yl)methylene)hydrazinyl) quinoline-3-carbaldehyde (7a-e).Newer synthesized series have been confirmed on the basis of IR,1H NMR and Mass spectroscopy. All the synthesized compound was evaluated for their anti-inflammatory activities by using carrageenan induced rat paw edema model. It was found that compound 7a and 7e shows highest potency among all the synthesized derivatives whereas Diclofenac Sodium was taken as standard drug.

Keywords: Vilsmeier-Haack reaction, Quinoline, Anti-inflammatory, Carrageenan induced rat paw edema model.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More