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Ram Sevak Verma*, Shobhit Srivastava, Bhumika Yogi and Sujeet Kumar Gupta


Synthesize a new series of Thiazole based derivatives (4a-e) and evaluated their Anticonvulsant activity. In the first stage, we synthesize an intermediate 2-amino-4-methyl thiazole,[2] followed by a condensation reaction in which thiourea[1] reacts with chloroacetone in the presence of water and sodium hydroxide to give a good yield product. Further, 2-amino-4-methyl thiazole[2] reacts with differently substituted acetophenone (3a-e) in the presence of benzaldehyde and a small amount of HCl via mannich base reaction to give 2-(4-methylthiazole-2-ylamino)-1-(substitutedphenyl)-3-phenylpropane-1-one derivatives (4a-e). The chemical structure of newly synthesized compounds characterized by the using spectral data 1H NMR, MS, and FT-IR. All the synthesized compounds were screened for their anticonvulsant activity, with maximal electroshock-induced seizure (MES) method. The electroconvulsiometer is used to generate seizures in mice. In the pharmacological study, the compounds 4a, 4d, & 4e were found to be a moderate effect against all seizures in mice, compared with standard drug Phenytoin.

Keywords: Thiazole, Electroconvulsiometer, Anticonvulsant activity.

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