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Abstract

FORMULATION AND IN-VITRO EVALUATION OF MICROSPONGE DRUG DELIVERY SYSTEM OF SALICYLIC ACID

Vilas S. Bhagat* and Sanjay R. Arote

ABSTRACT

A Microsponge Delivery System (MDS) is patented, highly cross-linked, porous, polymeric microspheres that can entrap wide range of actives and then release them onto the skin over a time and in response to trigger. It is a unique technology for the controlled release of topical agents and consists of microporous beads, typically 10-25 microns in diameter, loaded with active agent. In this study, Salicylic acid microsponges were prepared using liquid-liquid suspension polymerization method. The microsponges thus prepared, were evaluated for production yield, loading efficiency, particle size analysis, in-vitro release study of microsponges, and stability. Hence, the present work concluded that MDS has a great potential in topical delivery of drugs like Salicylic acid, with added advantage of reduction in irritation profile due to the controlled release and possible enhancement in the activity due to amorphization of the drug.

Keywords: Microsponge, microporous beads, particle size analysis.


[Full Text Article]

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