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Abstract

SYNTHESIS AND BIOLOGICAL ACTIVITY OF NEW CARBAMATE AND THIO CARBAMATE DERIVATIVES OF 4-AMINOBENZOHYDRAZIDE

Hari Prasad Vanam, E. A. Lohith, Dr. Bharath Kumar Momidi and
Dr. A. Sarangapani*

ABSTRACT

A series of new urea derivatives (3a-d) and thiourea derivatives (5a-f) have been synthesized in high yields (77-88%) by the reaction of substituted aryl isocynates (2a-d) and substituted aryl isothiocynates (4a-f) with 4-aminobenzoichydrazide (1). Their structures were established by spectral data. The title compounds were screened for anti-microbial activity. The present study revealed that Gram negative and positive bacteria such as E.coli & S.aureus were more susceptible to the solvent extracts. The methanol and acetone extracts of the samples were evaluated for in vitro anti-bacterial activity against human pathogenic bacteria Escherichia coli and Streptococcus aureus and the anti-fungal activity against Aspergillus niger and Aspergillus oryzae.

Keywords: Urea, thiourea, anti-bacterial activity, anti-fungal activity.


[Full Text Article]

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