Abstract

ENHANCEMENT OF SOLUBILITY OF NEVIRAPINE BY SOLID DISPERSION METHOD

*Sayali S. Bompilwar, Dr. Bharati V. Bakade and Bhagyashri M. Raut

ABSTRACT

The solid dispersion has attracted considerable interest as an efficient means of improving the dissolution rate and hence bioavailability of a range of hydrophobic drug. The present study was to enhance the solubility and dissolution rate of anti-HIV drug Nevirapine (NVP) by solvent evaporation method (SEM) and physical mixture (PM) by using polymer such as Hydroxy propyl cellulose (HPC) in different ratios like 1:1, 1:2. The solid dispersion in solid state was determined by the solubility studies. The interaction of Nevirapine with HPC was studied by using Fourier transform infrared spectroscopy (FTIR). Standard calibration curve and in vitro dissolution study of NVP was performed in 0.1 N HCl. Based on the solubility study, polymer HPC with ratio 1:1 by using solvent evaporation method and physical mixture respectively were selected for solid dispersion. The study shows that solubility of Nevirapine was successfully enhanced by using hydrophilic polymer such as HPC which also increased the bioavailability of Nevirapine.

Keywords: Nevirapine, solid dispersion, HPC, solubility, bioavailability, etc.