Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS APRIL ISSUE PUBLISHED
  • APRIL 2021 Issue has been successfully launched on 1 April 2021.

Abstract

ENHANCEMENT OF SOLUBILITY OF NEVIRAPINE BY SOLID DISPERSION METHOD

*Sayali S. Bompilwar, Dr. Bharati V. Bakade and Bhagyashri M. Raut

ABSTRACT

The solid dispersion has attracted considerable interest as an efficient means of improving the dissolution rate and hence bioavailability of a range of hydrophobic drug. The present study was to enhance the solubility and dissolution rate of anti-HIV drug Nevirapine (NVP) by solvent evaporation method (SEM) and physical mixture (PM) by using polymer such as Hydroxy propyl cellulose (HPC) in different ratios like 1:1, 1:2. The solid dispersion in solid state was determined by the solubility studies. The interaction of Nevirapine with HPC was studied by using Fourier transform infrared spectroscopy (FTIR). Standard calibration curve and in vitro dissolution study of NVP was performed in 0.1 N HCl. Based on the solubility study, polymer HPC with ratio 1:1 by using solvent evaporation method and physical mixture respectively were selected for solid dispersion. The study shows that solubility of Nevirapine was successfully enhanced by using hydrophilic polymer such as HPC which also increased the bioavailability of Nevirapine.

Keywords: Nevirapine, solid dispersion, HPC, solubility, bioavailability, etc.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More