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Abstract

“SOLID AS SOLVENT”- NOVEL TECHNIQUE FOR SPECTROPHOTOMETRIC ESTIMATION OF METRONIDAZOLE TABLETS USING SOLIDS (EUTECTIC LIQUID OF PHENOL AND METFORMIN HYDROCHLORIDE) AS SOLUBLIZING AGENT (MIXED SOLVENCY CONCEPT)

R.K. Maheshwari*, Shubham Patel, Simran Ludhiani, Asma Manzoor

ABSTRACT

The present research work provides a novel method to estimate spectrophotometrically, the metronidazole drug, in tablet formulations without the use of organic solvent. In the investigation, an attempt was made to show that solids can also be wisely used for forbidding organic solvents. The main objective of the present study is to demonstrate the solvency of solid. In the present study, a eutectic liquid (PMHCl 4:1) obtained by triturating phenol crystals and metformin hydrochloride in 4:1 ratio on weight basis was employed to extract (dissolve) metronidazole from fine powder of tablets. Distilled water was used for dilution purpose to carry out spectrophotometric estimation at 320nm without utilizing any organic solvent. The
solubility of metronidazole in distilled water at room temperature was found to be 7.28 mg/ml. while the solubility of metronidazole in PMHCl 4:1 was more than 130 mg/ml i.e., 18 times approximately. Proposed spectrophotometric analytical method is novel, rapid, free from toxicity of organic solvent, accurate and reproducible. The recovery studies and statistical data confirmed the accuracy, metformin hydrochloride and the tablet excipient did not interfere in the spectrophotometric estimation at 320nm.

Keywords: Mixed-solvency concept, metronidazole, phenol, metformin hydrochloride, spectrophotometric analysis, eutectic liquid.


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