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Abstract

METHOD DEVELOPMENT AND VALIDATION OF SUMATRIPTAN IN BULK AND PHARMACEUTICAL DOSAGE FORMS BY USING UV SPECTROPHOTOMETRIC METHOD

Monika M. Mahakal*, Rahul S. Solunke, Sarika, R. Wavhale and Rajkumar V. Shete

ABSTRACT

Sumatriptan succinate (sumatriptan) is a 5HT1D-Serotonin receptor agonist which is used to treat migraine and it has good vasoconstrictor properties. UV spectrophotometric method for analysis of sumatriptan from tablet formulation; method is based on measurement of UV absorbance of sumatriptan in distilled water. The drug obeyed the Beer’s law and showed good correlation. It showed absorption maxima at 241 nm; in distilled water. The linearity was observed between 2– 10 μg/ml. The results of analysis were validated by recovery studies. The Percent recovery range was found to be 97-110%. Validation experiments were performed to demonstrate System suitability, Specificity, Precision, Linearity, Accuracy Inter-day assay, intraday assay, robustness, ruggedness, LOD, &LOQ. The Proposed method was simple, sensitive & reliable with good Precise, Accurate, and Reproducible and rapid for the determination of Sumatriptan. While estimating the commercial formulation without interference of excipients & other additives hence this method can be used for routine determination of Sumatriptan in bulk and their pharmaceutical dosage forms.

Keywords: Sumatriptan, UV–Vis Spectrophotometry, Validation.


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