Abstract

A REVIEW ON GLIPIZIDE: SECOND GENERATION SULFONYLUREA

Neelam Somani*, Dr. Meenakshi Bharkatiya and Dr. K. S. Rathore

ABSTRACT

This is a brief summary about Glipizide, the second generation sulfonylurea in the treatment of noninsulin-dependent diabetes mellitus. Glipizide is a medium to long acting antidiabetic drug .it is practically insoluble in water and comes under biopharmaceutical classification system (BCS) class II. Its half life is 2-4 hrs. In comparison with the other sulfonylureas, glipizide has the fastest absorption and onset of action, as well as the shortest half-life and effect-duration. Thus the risk of long-lasting hypoglycemia is minute. Glipizide The occurrence of hypoglycemia with its use is uncommon and can be avoided by appropriate precautions and correct usage. These factors seem to recommend its use for the management of noninsulin-dependent diabetes mellitus.

Keywords: Glipizide, BCS, Hypoglycemia, Sulfonylurea.